Pasteurella pestis: Role of Pesticin I and Iron in Experimental Plague.
نویسندگان
چکیده
Loss of the genetic determinant for pesticin I in Pasteurella pestis results in concomitant loss of the plague coagulase and fibrinolytic factor. The median lethal dose for mice of an isolate lacking only these activities is increased by factors of about 10(1), 10(4), and 10(7) cells when administered by the intravenous, intraperitoneal, and subcutaneous routes, respectively. Virulence of the aforesaid strain can be enhanced in mice treated with 40 microg of ferrous iron. This response resembles that of Pasteurella pseudotuberculosis, a closely related species that normally lacks pesticin I.
منابع مشابه
Pesticinogeny: a characteristic useful for presumptive identification and isolation of Pasteurella pestis.
Current methods of identifying Pasteurella pestis rely heavily on tests specific for detecting fraction I, the envelope antigen. Pesticin I, a bacteriocin inhibitory for P. pseudotuberculosis, has been demonstrated in nearly all tested strains isolated from human infections. The results of using this characteristic as an identifying trait for P. pestis were compared with results reported for de...
متن کاملAnalysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore.
We have sequenced a region from the pgm locus of Yersinia pestis KIM6+ that confers sensitivity to the bacteriocin pesticin to certain strains of Escherichia coli and Y. pestis. The Y. pestis sequence is 98% identical to the pesticin receptor from Yersinia enterocolitica and is homologous to other TonB-dependent outer membrane proteins. Y. pestis strains with an in-frame deletion in the pestici...
متن کاملGenetic studies on the development of streptomycin resistance in Pasteurella pestis.
Meyer and Quan (1949) have demonstrated amply the therapeutic efficacy of streptomycin in experimental bubonic and pneumonic plague. Since streptomycin appears to be unique among the antibiotics in that high levels of resistance may occur in bacteria at a single mutational step (Bryson and Demerec, 1950), the occurrence of strains of Pasteurella pestis so resistant to this antibiotic as to be r...
متن کاملInfluence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. II. Plasma from plague-infected guinea pigs.
Stanziale, W. G. (Fort Detrick, Frederick, Md.) and J. D. White. Influence of guinea pig plasma factors on phagocytosis of Pasteurella pestis. II. Plasma from plague-infected guinea pigs. J. Bacteriol. 83:182-186. 1962.-The phagocytosis enhancing property of normal guinea pig plasma was altered during experimental plague infection. The most notable changes occurred in the plasma from afebrile, ...
متن کاملCharacteristics of a bacteriophage-infected strain of Pasteurella pestis isolated from a human case of plague.
A pseudolysogenic strain of Pasteurella pestis was isolated from a human in Vietnam. The culture contained a stable mixture of bacteriophage and phage-sensitive and phage-resistant P. pestis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Science
دوره 149 3682 شماره
صفحات -
تاریخ انتشار 1965